![]() ![]() ![]() ![]() Against all odds, some two millennia later, these incredible documents survive. The private diaries of one of Rome’s greatest emperors, the personal letters of one of Rome’s best playwrights and wisest power brokers, the lectures of a former slave and exile, turned influential teacher. All the harvest of the past is added to their store. Not satisfied to merely keep good watch over their own days, they annex every age to their own. “Of all people only those are at leisure who make time for philosophy, only they truly live. Memento Mori: Meditate On Your Mortality.How To Be A Stoic: 9 Stoic Exercises To Get You Started The Obstacle Is The Way by Ryan Holiday.The Daily Stoic by Ryan Holiday and Stephen Hanselman.Click the links below to navigate to a specific section or scroll and read the entirety of the page: So what is Stoicism? Who were the Stoics? How can you be a Stoic? We answer all your questions and more below. Frederick the Great, Montaigne, George Washington, Thomas Jefferson, Adam Smith, John Stuart Mill, Theodore Roosevelt, General James Mattis, -just to name a few-were all influenced by Stoic philosophy. It has been practiced by Kings, presidents, artists, writers and entrepreneurs. Stoicism has been a common thread though some of history’s great leaders. It’s a philosophy designed to make us more resilient, happier, more virtuous and more wise–and as a result, better people, better parents and better professionals. For those of us who live our lives in the real world, there is one branch of philosophy created just for us: Stoicism. ![]()
0 Comments
![]() ![]() ![]() This Windows 7 Games package is compatible with all builds of Windows 11, Windows 10, Windows 8.1 and Windows 8. Apart from the difficulty level, there are many other options as well in the Free Spider Solitaire games. Download Free Spider Solitaire for Windows to play exciting card game with multiple levels. Here is a Windows 7 Games package which solves this issue. Users can customize their settings in order to suit their individual system resolution. It has a fast response time and clean interface. There is no intermittence of any kind between deal and when users deal cards from the unused deck. Free Spider Solitaire 2020 has had 1 update within the past 6 months. A special mention needs to be made for the deal animation at this point in time. Download Free Spider Solitaire 2020 for Windows to play Spider Four Suits and four other spider solitaire card games. There are quite a few variations in the deck, background color, difficulty levels, sound effects and animations. It is clean and there is an absence of malware or adware during the installation. The Free Spider Solitaire does not need any additional requirements and is quite flexible. The game comes in three versions of difficulty: 1, 2, or 4 suits. Another benefit is that it requires moderate amount of system resources and does not hamper the speed and performance of the device. Spider Solitaire was introduced in the Microsoft Plus 98 addition pack for Windows 98. Windows Android iPhone bridge card game apps card game games for windows 7 card games card games for windows card games for windows 10 Classic Solitaire (Free) for Windows 10 3. The rules are easy to learn but will take. There is no need to pay even a single penny. Free Spider Solitaire is a free downloadable game that lets you play spider solitaire on your computer or laptop. There are innumerable games which can be enjoyed in this version. ![]() Once it is downloaded, users can enjoy the game for as long as possible. The first thing that comes to their minds is that it is free of cost. Be it amateurs or avid players, everyone will find this app impressive. You Can Free Download How To Play Spider Solitaire Windows 7 Spider Solitaire Game Png,Windows 7 Icon (1176x1200). It includes games that are based on a single suit. Download Spider Solitaire (4 suits) for Windows to accept the ultimate challenge of the classic card game. It can be downloaded onto any device that runs on Windows OS and is full of interesting features which users can make the most of. In order to have the same on PCs, laptops, mobile phones and other portable devices, the Free Spider Solitaire software is one of the better known options. It runs on both 32-bit and 64-bit systems with no dedicated 64-bit download provided.Spider Solitaire is one of the most popular card games of all and is ideal to take some time off work in order to recharge the brain. Previous versions of the operating system shouldn't be a problem with Windows 8, Windows 7 and Windows Vista having been tested. What version of Windows can 123 Free Solitaire run on?ġ23 Free Solitaire can be used on a computer running Windows 11 or Windows 10. Download and installation of this PC software is free and 10.3 is the latest version last time we checked. With a ton of possibilities, this suite of games is perfect for long train or plane journeys.ġ23 Free Solitaire is provided under a freeware license on Windows from card games with no restrictions on usage. Home Windows How to Bring Back the Classic Windows 7 and XP Games on Windows 10 and 11 By Jack Slater Published Still reminiscing about playing a few rounds of Spider Solitaire or Space Cadet pinball Here's how to bring them back on Windows 10 and 11. The package offers a lovely interface, a help system and detailed information about each Solitaire game included in the package.Įach game includes the average duration of the game, the level of difficulty and the likelihood of winning (so average stats.)ġ23 Free Solitaire is well-organized and the statistics are useful. To my disappointment, Spider Solitaire in Windows 10 is of poor quality, compared to Spider Solitaire in Windows 7. Advertisement Multiple solitaire styles: classic, pyramid, flower and more.Īn exciting collection of 12 Solitaire card games with statistics.ġ23 Free Solitaire is a freeware collection of classic solitaire games for the PC. Napoleon Lombard Created on SeptemWindows 7 Spider Solitaire I recently downloaded Windows 10. ![]() ![]() Where: 3201 S Lamar Blvd, Austin, TX 78704Ī less-crowded alternative to Barton Springs, Deep Eddy Pool has two areas: one body of water filled with spring water, and another filled with regular pool water. If you’re looking for a chicken fried steak, they make a great one. Featuring local musicians and cold beer, it’s a famous dancehall located in south Austin that’s definitely worth popping into to scoot your boots. If you want to go two-stepping, the Broken Spoke is the place to do it. ![]() Where: 1315 S Congress Ave, Austin, TX 78704 The Broken Spoke Stevie Ray Vaughn played it way back when, and there’s hardly a better spot in town to see country, bluegrass, or jazz acts on a whim. Located on Congress Avenue, the Continental Club features local acts and rarely requires booking tickets in advance. Where: 912 Red River St, Austin, TX 78701 The Continental Club When you’re there, check out Stubb’s across the street, another classic venue. Check out the venue’s list of acts before you arrive in Austin, and book your tickets ahead of time-you’ll need them for this spot. With a raised staircase in the back, you can show up to a concert late and still get a great view of the band. The Mohawk is one of the best concert venues in the country because no standing spot is a bad one. Where: 2313 Red River St, Austin, TX 78705 Check out what Johnson’s oval office looked like, learn how legislation enacted in the 1960s still affects us today, forget to stop and don’t forget to stop by Beyond the Wildflowers, an exhibition dedicated to his wife, Lady Bird Johnson. Where: 3809 W 35th St, Austin, TX 78703 LBJ Presidential LibraryĬelebrating the 36th president of the United States, the LBJ Library will take you back to the 1960s. It surrounds Lake Austin and is a beautiful spot to take in nature and an interesting collection of contemporary art. ![]() The Contemporary has two locations-a downtown gallery, and a sculpture garden called Laguna Gloria uptown. Where: 200 E Martin Luther King Jr Blvd, Austin, TX 78712 The Contemporary But the thing you can’t miss here is the chapel Ellsworth Kelly designed, featuring stained glass panels. Part of the University of Texas at Austin’s campus, it features an excellent collection of both modern and colonial-era paintings. The Blanton is one of the largest university art museums in the United States. ![]() ![]() ![]() One of the most apparent themes in Beau Is Afraid is guilt. Because then I would be trying to bend the world to what I was feeling when it should be the other way around.” Those things affect me so much that to make any decision to try to feel certain about who the character is would be a mistake. It’s how talk to each other, the set, the other actors, the wardrobe, the look, the hair-all of that has to come together. “Everything has to be a reaction to the environment,” he says. Given the ambiguous nature of the movie, viewers are still seemingly left to decide if Mona’s death and the woes that plagued Beau in its wake were all orchestrated by Mona as a punishment for her disloyal son, or if everything was in Beau’s head all along.įor Phoenix’s part, he says he approached playing Beau from a place of uncertainty about the truth of the character. “Their relationship is complicated because Mona gives so much love-the uncontrollable kind that can move mountains but also create anger and resentment between giver and receiver,” Armen Nahapetian, who plays a 12-year-old version of Beau in a flashback sequence, said in the production notes. That’s like the most Jewish thing.'” The end all be all of mommy issuesīy the end of the film, Beau discovers that Mona is not really dead and instead elaborately faked her own death simply to see if he would react in a way that she deemed appropriate. “They’re always punishing people for not honoring them in the right way. “Greek tragedies always really made me laugh because the gods in those plays are so petty and so ridiculous,” Aster says. The Greeks come into play as well, with odes to Oedipus Rex, Medea, and, of course, The Odyssey, assuming a significant role in Beau’s hero’s journey. “He captures intense feelings about what it means to walk around our cities and live inside our homes, the things that haunt us about our parents, the mayhem of culture and capitalism.” “Ari Aster shows us a Kafkaesque nightmare not unlike the one we are living through today,” Parker Posey, who plays the adult version of Beau’s lifelong love interest Elaine, said in the production notes. “He needs to just get some therapy,” Phoenix interjects.Īs for the anarchic nature of the city-named Corrina, according to Aster, in reference to the 1994 Ray Liotta movie Corrina, Corrina-what we see is likely more a product of Beau’s anxieties than a true interpretation of reality.īut other literary influences also abound, ranging from Franz Kafka to Jorge Luis Borges to Virgil to Laurence Sterne to Miguel de Cervantes to Tennessee Williams. It was a big distraction in pre-production just coming up with really stupid names for things, titles for fake movies and names for fake products and fake band names…You see names of bands like ‘Anal Puke,’ ‘Death By Anal,’ ‘Murder By F-ck,’ ‘Butt Finger.'” “And part of the fun for me was how many details we could cram into the frame. “I learned this term ‘chicken fat,’ which is the idea of jamming the background with as many gags as possible,” he says. Specifically referencing a drawing of “a penis in a tuxedo vomiting,” Aster says that the only rule for these gimmicks was that they had to reflect his sense of humor. Nearly every surface we see as Beau makes his way home to his sparse, lonely apartment is covered in graffiti or lewd advertisements-details that Aster says he continued to add throughout the filming process. “It’s unpleasant in all the ways that our world is unpleasant,” Aster says. ![]() ![]() ![]() The only other text on the dial side of the watch is the small “RM66” badge that extends from under the rehaut between the 7 o’clock and 8 o’clock hour markers. ![]() The top of the rehaut features the “Richard Mille” name in white letters, while the obligatory “Swiss Made” signature appears in its usual place at the 6 o’clock location. The hour markers themselves are finished with green-glowing lume and appear in the shape of guitar picks, while the pair of centrally mounted skeletonized baton hands also feature luminous tips for added visibility in the dark. Surrounding the interior perimeter of the crystal is a rehaut made from grade 5 titanium with a black galvanic treatment, and fitted to this component are luminous hour markers that extend from it on golden lancet arches for a highly sculptural display from both the front and back side views of the watch. In order to achieve their intricate shape and realistic texture, the various components of the hand are first machine milled before being handed off to master Genevan engraver Olivier Vaucher, who adds detail and finishes them by hand before giving them a micro-blasted finish. The three-dimensional skeleton hand essentially holds the components of the internal movement, and its three non-outstretched fingers can be seen grasping the other side of the movement when viewed through its sapphire display caseback. Sitting front and center inside the watch is a human skeleton hand that is crafted from 5N red gold, with its index and pinky fingers outstretched to form the popular rock and roll “horns” hand gesture. However, rather than simply showcasing its movement, the entire internal design is based around an intricate rose gold sculpture. Like most Richard Mille watches, the new RM 66 Flying Tourbillon features a largely open-worked aesthetic. The tip of the crown gets finished with a small skull insignia as a subtle nod to the RM 052 Tourbillon Skull watch, and due to its intricate structure, machining and finishing just one of these spider-shaped winding crowns takes a full 12 hours to properly complete. The crown itself is constructed from polished grade 5 titanium, and it is crafted in the shape of a spider, with its legs surrounding a black rubber collar and synthetic red ruby. Since the Richard Mille RM 66 Flying Tourbillon is powered by a manually wound movement, this innovative feature eliminates the possibility of accidental overwinding and prevents wear and damage to both the stem and mainspring. Curved sapphire crystals with anti-glare treatment are fitted to both the dial side of the watch and its caseback, while the case itself is held together with 20 titanium spline screws and features two Nitrile gaskets that help create 50 meters of water resistance.Īt the 3 o’clock location is a rather ornately designed torque-limiting winding crown that automatically disengages when the tension in the mainspring barrel reaches an optimal level. Set into the center titanium caseband are 5N red gold inserts, which have been given a prominent “clous de Paris” pattern that is intended to be reminiscent of the studs on punk belts. The bezel and caseback are crafted from black Carbon TPT, while the middle caseband is made from grade 5 titanium and features brushed pillars with polished bevels. The case of the Richard Mille RM 66 Flying Tourbillon follows the same multi-component curved tonneau design that defines the vast majority of the brand’s other models, and it measures 42.7mm-wide by 49.94mm lug-to-lug, with an overall thickness of 16.15mm. Continuing this theme of bold and slightly irreverent designs carried out at the highest possible levels is the latest release from Richard Mille - the RM 66 Flying Tourbillon, which is a 50-piece limited edition that represents the brand’s tribute to the world of rock and roll music. However, it’s ultimately hard to call a watch a mere “novelty” when it features heavy-hitter complications, state-of-the-art materials, and costs as much as a very nice house in many parts of the U.S. ![]() If Richard Mille watches were of lesser quality and priced within the realm of possibility for most people, there would likely be some who would consider them to be horological novelties. Everything the brand produces is executed to incredibly high standards, yet many of its designs have a certain lighthearted nature to them, even when they are ultimately rather serious timepieces. There are few companies that approach high-end watchmaking with the same fun and playful irreverence as Richard Mille. ![]() ![]() ![]() ![]() He serves as an example to children everywhere that they, too, can accomplish greatness through devotion and commitment to their studies and passions, regardless of their background.ĪLSO READ: Brilliant Nigerian woman becomes Professor at Canadian university 8 years after earning PhD Degree, celebrates unique achievementĪdelakun was also a member of the theatre club and the Thespian Honours Society, in addition to his academic accomplishments. Timi Adelakun’s tale is one of tenacity, hard work, and resilience. “I guess after graduation, go a little bit higher, but that’s my number,” Adelakun told WSVN. ![]() He accomplished this distinction by attaining the highest GPA in the school’s history, 5.6.Īdelakun attributes his academic success to the American College of Education programmes, Advanced Placement (AP) classes, and Broward College courses that allowed him to obtain college credits while still in high school.ĪLSO READ: Brilliant Nigerian student graduates with a 4.93 CGPA, wins 6 awardsĪdelakun was unable to attend traditional graduation celebrations due to the coronavirus outbreak, but he stated that he was nonetheless optimistic about his future and his desire to reach new heights and step outside of his comfort zone. We celebrate focus and resilience.Timi Adelakun, an excellent alumnus of South Broward High School in Hollywood, Florida, made history by being the school’s first African American valedictorian. It’s very much likely for the CGPA to receive an increase. Timi has shown his excitement and said on his graduation, A record unmatched since the school was founded. Today, Timi is not graduating yet but has stolen the face of the entire show as the first black valedictorian, South Broward High School’s graduating class of 2020, Florida. I’ve been taking over 20 college courses worth of credit, and because of that, my AP credits, my Ace credits and my dual enrollment credits boost my GPA.” At the same time, they offer AP courses and at the same time, they offer Broward College courses. South Broward High School, which is an Ace Program school, and each Ace class is college credit. In his words, “South Broward sets you up to start off with college-level courses, so you’re pretty much in a good position GPA wise. While asked how he could attain the feat and sustain it,Īdelakun said he had a solid foundation in his grades early enough which he He has revealed that he is excited about it and would definitely make a speech that will provide some very positive reinforcement for the students. While Timi isn’t yet in his finals, he’d be a privilege to charge up the graduating class of 2020. The graduation has been on hold due to the pandemic but proposed to come up virtually. It’s not any of our faults.” he told Yahoo newsmen. I miss his physical presence and involvement. In his words, “He left when I was in the first grade. It was at this point he remembered his Dad who hadn’t been available physically for him. Reasons for him, Pomona not only offered him a full scholarship but also has facilities that would make his overall college experience a memorable one. He will attend Pomona College, a private liberal arts college in Claremont, California. On this basis, Timi has been offered a scholarship from the various institution. ![]() Speaking with ABC News, He said Coming from a low-incomeĬommunity, it means a lot in general because of the way I was brought up.” With this seemingly uncertain situation, Timi remained focused in his pursuit for excellence in the lone and strange land. He joggled a number of things together to make both ends meet. It was indeed with mixed feelings he took the news.įinancial constraints have been a big issue to deal with for him. In Hollywood, Florida when the news of him being the student with the highestĬGPA recorded in the history of the school was aired, which happened to be aĥ.604 GPA. Timi Adelakun Father’s name is withheld from the public.ĭuring this year’s graduation from South Broward High School Unfortunately, his father was deported over 10years ago when he was just starting off his education. In 1981, his father relocated to the United States of America for educational purposes. His parents were born and bred in Nigeria. Timi Adelakun is a resourceful 18-year-old young boy who has spent a good number of his years in the United States of America. ![]() ![]() © 2022 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. Safety is similar to OIT for other foods.Īllergy cashew cross-reactivity immunotherapy tree nuts. All (n = 44) patients consuming a low cashew dose for ≥6 months following desensitization passed a full-dose cashew OFC.Ĭashew OIT desensitizes most cashew-allergic patients and cross-desensitizes to pistachio. Following cashew desensitization, all pistachio (n = 35) and four of eight walnut co-allergic patients were cross-desensitized to the respective nut. Desensitized patients had decreased SPT, sIgE, basophil reactivity, and increased sIgG4, following treatment. Three patients (6%) were treated with injectable epinephrine for home reactions. An additional three patients were desensitized to 1200 mg cashew protein, and three patients stopped treatment. Patients with co-allergy to pistachio or walnut were challenged to the respective nut.įorty-four of 50 OIT-treated patients (88%) compared to 0% in controls tolerated a dose of 4000 mg cashew protein at the end of the study (odds ratio 8.3, 95% CI 3.9-17.7, p < 0.001). Patients fully desensitized to cashew were instructed to consume a dose of 1200 mg cashew protein for 6 months and were then challenged to a full dose. Full desensitization rate and associated immunological changes in both groups were compared. Co-allergy to pistachio and walnut was determined. ![]() His SPT was 13 mm wheal to pistachio (cashew was unavailable) and his specific IgE was 7.44 to both cashew and pistachio. Fifteen cashew-allergic patients who continued cashew elimination served as observational controls. JanuPeanuts and Anaphylaxis Due to Cashew Nut Question: Recently I saw a one year-old child with a history of well-controlled eczema with anaphylaxis to cashew nut. Oral immunotherapy (OIT) is a treatment option for patients with milk, egg, and peanut allergy, but data on the efficacy and safety of cashew OIT are limited.Ī cohort of 50 cashew-allergic patients aged ≥4 years, who were consecutively enrolled into cashew OIT (target dose 4000 mg protein) between 4/2016 and 12/2019. ![]() ![]() ![]() This isn't as easy as scanning a multi-page file with an automatic document feeder (ADF)-it does nothing to help put the next page on the flatbed-but it's as easy as it can be without an ADF.įrom Fully Automatic to Full Manual ControlĮpson has also carried forward its full range of choices for scanning modes, ranging from fully automatic to fully manual. After scanning each page, you can add another page by pressing a button on the screen or the scanner, or end the scan by pressing a different button. The other three are for copying (by sending the scan to your printer), e-mailing (by launching an e-mail message on your PC and adding the scan as an attachment), and saving to a PDF file (with the option set by default to recognize the text and save it in searchable PDF format).Īs I've mentioned in other reviews, the Epson utility offers one particularly nice touch for scanning to PDF files. One of the buttons simply brings up the scan utility on your PC. The utility lets you start a scan either from your computer or by using one of the four buttons on the scanner itself. The V600's scan utility will be familiar to anyone who's worked with a recent Epson scanner or MFP. ![]() ![]() Also included are Adobe Photoshop Elements and Abbyy FineReader 6.0 Sprint for optical character recognition (OCR). Like most scanners, the V600 comes with TWAIN and WIA drivers, so you can scan from most programs with a scan command. I installed it on a system running Windows Vista, but according to Epson, it also comes with drivers and a full set of software for Windows 7, XP, 2000 and Mac OX 10.3.9 through 10.6. Simply install the software, plug in the power cord and supplied USB cable, and turn the scanner on. The V500 includes Digital ICE for film only. In particular, it includes Digital ICE-the hardware-based approach for digitally removing dust and scratches-for both prints and film. Despite the evenly spaced model numbers, it's much closer in price and capability to the V500, but it offers some important extras. The V600 fits in Epson's line between the less expensive Editors' Choice Epson Perfection V500 Photo, scanner and the more expensive Epson Perfection V700 Photo. Best Hosted Endpoint Protection and Security Software. ![]() ![]() Her Saint Jane bears little relation to the footage of the young, clearly overwhelmed Fonda we see in North Vietnam projected onto the back wall. And Archer plays up to the heavily weighted script, portraying Fonda with a detached serenity that verges on irritating. It also doesn’t help that so many of the veterans are written so one-dimensionally: each feels like an outline of a type rather than flesh-and-blood. In theory, this is a powder-keg situation, but, crucially, Fonda never seems in danger. And when they’re not doing that, they walk to a spotlight in the wings to deliver fairly stilted monologues. In part, this is because of the flat staging – the cast occupy a row of chairs from which they take turns to yell at each other. And even in 2005, a man spat tobacco juice in the 68-year-old actress’s face at a book-signing.īut this production never really sparks into life. After all, at the height of her activism, her photo adorned the portable toilet mats used by the US Armed Forces to piss on. The idea of Fonda confronting a room full of furious former soldiers who believe she betrayed them and her country is ripe with dramatic potential. But the play never strays far from her side, as Jastrow uses documentary footage and a detailed outline of her beliefs to portray her as a preternaturally clear-sighted humanitarian. Beyond a few media interviews, we don’t know really know how the actual meeting panned out, other than that Fonda’s film went ahead. In spite of the title, this isn’t a genuine trial of Fonda’s actions in one of the most controversial periods of American history. Following the burning of her effigy and threats to disrupt the making of her latest film, Stanley & Iris, co-starring Robert de Niro, Fonda held a meeting with angry Vietnam vets. Here, Hollywood writer Terry Jastrow directs his wife, Anne Archer, in his recreation of what happened behind closed doors during a little known event in Waterbury, Connecticut, on 18 June, 1988. It outraged American Vietnam veterans, who dubbed ‘Hanoi Jane’ a traitor to her country and to the memories of those soldiers who had died. I didn’t know what else to do.” She also debunks myths about her trip in the blogpost, saying that “the lies distort the truth of why I went to North Vietnam and they perpetuate the myth that being anti-war means being anti-soldier.The image of actress Jane Fonda sitting, smiling, on an NVA anti-aircraft gun during her 1972 tour of North Vietnam in protest against America’s involvement in the war has dogged her career ever since. Please, you can’t let them be published.’ I was assured it would be taken care of. It’s going to look like I was trying to shoot down US planes.’ I pleaded with him, ‘You have to be sure those photographs are not published. I got up, and as I started to walk back to the car with the translator, the implication of what had just happened hit me. ![]() “I hardly even thought about where I was sitting. In a lengthy blog on her own website in 2011, she gives her side of the story. This famous person goes and does something that looks like I’m against the troops, which wasn’t true, but it looked that way, and I’m a convenient target.” and she went to Vietnam to advance her husband’s career.”įonda added that she understood this anger, and that she often met with veterans to discuss it: “I’m a lightning rod. ![]() One protestor told the Frederick News Post, “She got Americans killed. There was outrage at the pictures and Fonda was branded a traitor, but she has frequently regretted them. The series of photos were taken during Fonda’s visit to Hanoi, where she met with North Vietnamese troops, and was pictured sat on an anti-aircraft gun being used to target American planes. Protestors had massed outside the event with copies of the photo and signs reading “Forgive? Maybe. “It hurts me and it will to my grave that I made a huge, huge mistake that made a lot of people think I was against the soldiers,” she said at a personal speaking engagement in Frederick, Maryland. Jane Fonda has once again expressed regret over the infamous ‘Hanoi Jane’ picture taken of her during the Vietnam war. ![]() ![]() 1, the sequence on the positive strand 5′-GACA|TGTC-3′ is a palindrome since GACA is followed by its complement CTGT, but appearing in reverse order as TGTC 2. ![]() In DNA, palindromes are defined as a sequence of nucleotides that are followed by its complement sequence appearing in reverse order 1. The catalog of palindromes in the reference genome and 1000 Genomes is being made available here with details on their variations in each individual genome to serve as a resource for future and retrospective whole-genome studies identifying statistically significant palindrome variations associated with diseases or traits and their roles in disease mechanisms. The analysis of disease/trait-associated single-nucleotide polymorphisms in palindromic regions showed that disease-associated risk variants are 14 times more likely to be present in palindromic regions than in other regions. We found that ~30% of the palindromes exhibit variation, some of which are caused by rare variants. ![]() In this work, we computed and analyzed the palindromic sequences in the human genome and studied their conservation in personal genomes using 1000 Genomes data. Palindromic mutations are linked to many human diseases, such as neuronal disorders, mental retardation, and various cancers. Palindromes are distributed throughout the human genome and play significant roles in gene expression and regulation. ![]() A palindrome in DNA is like a palindrome in language, but when read backwards, it is a complement of the forward sequence effectively, the two halves of a sequence complement each other from its midpoint like in a double strand of DNA. ![]() |